Protective Role of Apigenin Against Rotenone Induced Model of Parkinson’s Disease: Behavioral Study
نویسندگان
چکیده
Rotenone is a pesticide that has been shown to cause degeneration of dopaminergic neurons within the substantianigra and striatum. In this study, we investigated the protective effects of Apigenin on rotenone induced dopaminergic neurotoxicity. Adult male wistar albino rats were injected with rotenone (6μg/1μl in DMSO) or vehicle (1μl DMSO) into the right substantianigra pars compacta (SNpc) under stereotaxic surgery. Two varying doses of Apigenin (10 mg/kg and 20 mg/kg/ day, i.p.) were administered for 14 days. The significant increase in catalepsy, postural instability, impaired motor coordination, decrease in locomotor activity, and the decrease in rearing behavior caused due to rotenone induction was attenuated by treatment with varying doses of apigenin. These results suggest that apigenin may serve as a promising therapeutic tool in Parkinson’s disease.
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